External Medicine
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Hidradenitis Suppurativa
ETIOLOGY
Genetics
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A twin study reported a heritability of HS of 77%, which is higher than what has been previously reported for psoriasis, (68%) and RA (60-75%), and on par with Crohns (75%). 33052394
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note to self: not particularly savvy at interpreting these heritability statistics
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CLINICAL FEATURES
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Patients with HS can present with sepsis-like features -- meet SIRS criteria, leukocytosis, tachycardia -- but RARELY have fever. 38395228
Impact on Pregnancy
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Some evidence HS is associated with worse maternal and fetal outcomes during pregnancy even when controlling for maternal comorbidities that were significantly higher in HS patients than non-HS patients. 39412794
TREATMENT
Surgical
Definitions
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Recently, an attempt to standardize surgical definitions was proposed to clarify what is being performed. 36811866
Emerging Therapies
Ben Abdallah H, Bregnhøj A, Emmanuel T, Ghatnekar G, Johansen C, Iversen L. Efficacy and Safety of the Heat Shock Protein 90 Inhibitor RGRN-305 in Hidradenitis Suppurativa: A Parallel-Design Double-Blind Trial. JAMA Dermatol. 2024. PMID: 38055242.