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Hidradenitis Suppurativa

ETIOLOGY

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Genetics                                                                                                                                                                                                         ​​

  • A twin study reported a heritability of HS of 77%, which is higher than what has been previously reported for psoriasis, (68%) and RA (60-75%), and on par with Crohns (75%). 33052394

    • note to self: not particularly savvy at interpreting these heritability statistics​

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CLINICAL FEATURES

  • ​​Patients with HS can present with sepsis-like features -- meet SIRS criteria, leukocytosis, tachycardia -- but RARELY have fever. 38395228

TREATMENT

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Surgical                                                                                                                                                                                                          

Definitions​​​

  • Recently, an attempt to standardize surgical definitions was proposed to clarify what is being performed. 36811866

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Emerging Therapies                                                                                                                                                                                      

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Ben Abdallah H, Bregnhøj A, Emmanuel T, Ghatnekar G, Johansen C, Iversen L. Efficacy and Safety of the Heat Shock Protein 90 Inhibitor RGRN-305 in Hidradenitis Suppurativa: A Parallel-Design Double-Blind Trial. JAMA Dermatol. 2024. PMID: 38055242.

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