Other (Uncommon or Unusual) Diseases

DARIER'S DISEASE

Vesicular Darier's disease is a rare variant of the disorder where patients develop numerous vesicles and bullae concurrently or independent of the more typical lesions found in Darier's disease.

Inhibition of type II cytokines like IL-4 and IL-13 have been effective in case reports. 39046749

Most wounds (90%) were located on the extremities, with 69% involving extensor surfaces (e.g., posterior upper or anterior lower extremities).
Common wound bed features included devitalized tissue (60%), such as eschar or slough, particularly in larger or chronic wounds.
Wounds varied in size: 20% were small (<1 cm²), 56% medium (1 cm² to hand-sized), and 24% large (larger than hand-sized).
Chronic wounds (present for >3 months) were more likely to be large and have necrotic wound beds, compared to acute wounds (<1 month).

The majority of wounds (87%) were linked to injection drug use, with xylazine exposure exacerbating tissue injury due to its vasoconstrictive and cytotoxic effects.

Signs of infection included erythema (58%) and purulence (25%), with some wounds showing exposed deep structures (e.g., bone, tendon).
Cultures revealed Staphylococcus aureus (including methicillin-resistant strains), group A Streptococcus, and other pathogens in infected wounds.